Proteinase-3 (PR-3) Antigen


SKU: PR3-3000

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The Proteinase-3 (PR-3) antigen is 29 kD protein found in the primary granules of neutrophils and monocytes. It is a serine protease with broad proteolytic activity against a variety of extracellular matrix proteins (1). ImmunoVision’s PR-3 is purified fom a human promyelocytic cell line using detergent extraction, salt fractionation, and chromaographic techniques. Anti-neutrophil cytoplasmic antibodies (ANCA) are autoantibodies against various lysosomal enzymes (2). Staining by indirect immunofluorescence (IFA) shows two main staining patterns: cytoplasmic (c-ANCA) and perinuclear (p-ANCA) (2,3). The c-ANCA pattern is caused by autoantibodies to PR-3 (4,5). Anti-PR3 autoantibodies are found in 84-100% of patients with Wegener’s granulomatosis (3,6). In addition, PR-3 antibody titer may correlate with disease activity (2).

Product Code:

Code Amount Price Inquiry
0.1 mg
1 mg


  1. Brockmann H, et al. Arthritis Res. Vol 4:pg 220-225 (2002).
  2. Peter JB. Use and Interpretation of Tests in Clinical Immunology, Eight Edition. Specialty Laboratories, Inc. Santa Monica, CA. pg 174-177.
  3. Hagen EC, et al. J.Immunol. Methods. Vol 196:pg 1-15 (1996).
  4. Savage COS, et al. Lancet. Vol 349:pg 553-558 (1997).
  5. Hagen EC, et al. Blood. Vol 91:pg1996-2002 (1992).
  6. Zhao MH and Lockwood CM. J. Immunol. Methods. Vol 197:pg 121-130 (1996).


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